(B, C) MTOC and lysosome polarity indexes and (D) quantification of Lamp-1+ rings around Ag-coated beads in control and Vamp-7–silenced cells after 2 h of activation; ≥20 cells/condition; two independent experiments. (B) siCtrl p < 0.0001; siVamp-7 B p < 0.0001. Unpaired t test. (C) siCtrl p = 0.0006; siVamp-7 B p = 0.0029. Unpaired t test. (D) p = 0.0013. Mann-Whitney test.

source: Obino, D., Diaz, J., Sáez, J. J., Ibañez-Vega, J., Sáez, P. J., Alamo, M., … & Yuseff, M. I. (2017). Vamp-7–dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes. Molecular biology of the cell, 28(7), 890-897.